Methylisothiazolinone

Methylisothiazolinone(MIT) CAS 2682-20-4

Methylisothiazolinone is a powerful, broad-spectrum heterocycle organic compound predominantly utilized as an outstanding biocide, preservative, and antimicrobial agent. Sinochem operates as a premier, high-capacity international manufacturer and bulk supplier of premium-grade Methylisothiazolinone solutions.

As a versatile, low-dosage preservative platform, MIT effectively eliminates and controls the proliferation of a wide spectrum of gram-positive and gram-negative bacteria, fungi, and yeasts. Engineered to meet strict global manufacturing standards, our MIT formulations offer exceptional chemical stability across an extended pH matrix and demonstrate excellent physical compatibility when blended seamlessly with diverse industrial emulsifiers, anionic/cationic surfactants, and active protein components.

  • Broad-Spectrum Efficacy: Achieves robust, long-term antimicrobial eradication and inhibition at highly cost-effective, minimal dosing thresholds.
  • Excellent Process Compatibility: Can be introduced safely at almost any processing stage, providing great ease of operation for automated formulation systems.
  • Robust Environmental Stability: Highly light-stable and fully reliable across a wide working pH window of 2–10, with sustained thermal resistance up to 80°C.
  • Optimal Water Miscibility: Fully miscible with water phases, facilitating smooth, uniform integration without phase separation or sediment formatting.
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2-Methyl-4-Isothiazolin-3-one Description

Name: Methylisothiazolinone (MIT)

CAS NO.:  2682-20-4

Density: 1.25 g/cm3

Boiling point: 182.8±23.0 °C at 760 mmHg

Melting point: 47.0℃-51.0℃

Flash point: 64.3±22.6 °C

Appearance: Colorless, with a certain odor

Package: 25kg stacking barrels, 200kg double-ring barrels, and 1000kg IBC barrels.

Storage:  Store in a sealed container indoors at below 40°C, avoid freezing and direct sunlight.

Hazards: Store in tightly sealed, light-resistant HDPE containers at controlled room temperatures (15 -30℃). Protect from direct sunlight, freezing, and strong oxidizing or reducing agents. Keep containers purged with inert gas or tightly capped to maintain active chemical integrity.

Regulatory & Hazards Statement: MIT is a potent skin sensitizer and corrosive material in concentrated forms. Industrial operations must employ full protective equipment (fluororubber gloves, safety goggles, respirator). Formulation in personal care products must adhere strictly to regional cosmetic regulations (e.g., maximum allowable concentration of 15 ppm in rinse-off applications under EU SCCS standards; prohibited in leave-on products).

Isothiazolinone Technical

Technical Parameter Pure MIT MIT 50% Aqueous Solution
Appearance Off-white crystalline solid Clear, light yellow liquid
Active Content ≥ 99.0% 50.052.0%
Density (20 ℃) 1.25 g/cm3 1.15-1.21 g/mL
Melting Point 47.0–51.0 ℃ N/A (Liquid phase)
pH Range Stability 2.0-10.0 2.0-10.0
Trade Name Equivalents Neolone 950, ProClin 950 Kordek 50C, Acticide M50

MIT Applications

  • Personal Care Products & Advanced Cosmetics: MIT serves as a critical, regulatory-compliant preservative platform in daily rinse-off personal care items. It effectively prevents microbial spoilage and hazardous contamination during regular consumer opening and usage cycles in high-volume products such as shampoos, hair conditioners, shower gels, liquid hand soaps, and specialized facial cleansers.
  • Premium Paints, Coatings & Polymer Emulsions: In the industrial coatings sector, wet-state spoilage is a persistent challenge. Our MIT formulations provide excellent in-can preservation for waterborne paints, decorative coatings, and industrial polymer binders, successfully preventing mold formation, gas generation, and viscosity loss during extended storage periods.
  • Industrial Recirculating Cooling Water Systems: Biological slime buildup on heat-exchanger tube walls significantly decreases thermal efficiency and induces microbially influenced corrosion (MIC). MIT acts as an aggressive water treatment biocide, piercing cellular membranes to halt microbial growth, control bio-slimes, and prevent piping system clogging.
  • High-Output Papermaking & Pulp Milling Lines: Within the warm, wet environment of paper mill processing loops, slime-producing bacteria and fungi can degrade paper quality and cause frequent web breaks. Implementing MIT prevents slime formation, protects raw cellulose integrity, and ensures superior final paper grade consistency.
  • Specialized Metalworking Fluids & Cutting Oils: Water-soluble metalworking cutting fluids provide an ideal breeding ground for bacteria, leading to foul odors, fluid splitting, and decreased tool lubrication. MIT extends the service life of cutting fluids and lubricating oils by providing stable, long-lasting bactericidal protection under high-shear operations.
  • Auxiliary Sectors: Beyond primary application areas, MIT is highly effective as an anti-spoilage additive for industrial adhesives, structural starches, textile spinning finishes, leather tanning liquors, and high-temperature oilfield reinjection waters.

Q1: What is the main operational difference between using pure MIT versus CMIT/MIT blends?

A: CMIT/MIT blends (typically at a 3:1 ratio) offer highly aggressive, fast-acting biocidal action but are structurally sensitive to high pH environments (>8.5) and reducing agents. Pure Methylisothiazolinone (MIT 50%) provides a much broader pH stability window (up to pH 10.0) and superior thermal resistance up to 80°C, making it ideal for harsh alkaline industrial systems.

Q2: Can your MIT 50% solution be directly added to waterborne polymer coatings?

A: Yes, our MIT 50% aqueous formulation features an optimized surfactant compatibility matrix. It can be introduced directly at any phase of the coating manufacturing process—including the pigment grind or post-addition phases—without causing polymer shocking, coagulation, or color drift.

Q3: How do you ensure the chemical stability of MIT during trans-oceanic maritime transport?

A: Atmospheric exposure and extreme heat can affect MIT stability. We package our products in tightly sealed, UV-stabilized, high-density polyethylene (HDPE) barrels and highly recommend maintaining storage temperatures under 40°C. For bulk container shipments traveling through hot tropical zones, we offer nitrogen-blanketed scaling option profiles to ensure zero quality degradation upon arrival.

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Methylisothiazolinone (MIT), with the chemical formula C4H5NOS, is an important isothiazolinone compound. Initially developed as a bactericide and preservative in […]

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2-Specialty Chemicals